I had an opportunity a few months ago to create a presentation using Prezi for graduate school. I waited a bit too long and was not able to really play around with the tools Prezi offers before I had to give the talk. I am used to using PowerPoint and Keynote, but Prezi was a completely new experience. The learning curve is steep, but worth navigating.

Take a look at some of the featured Prezi's, especially if you are about to create a presentation. This will give you some great inspiration, and help you think about your presentation in a new way. Forget about slides and points, and start thinking about illustrating your core ideas. How do you imagine your topic when you close your eyes? Do you see static slides with pictures and text, one after the other? Probably not. Prezi lets you zoom around from one idea to the next and connect them all together with... whatever you want! Just make sure you have something interesting to say, or you will be upstaged by your own presentation.

The editing controls are not as intuitive as I would like, but watching the tutorials will help you get a handle on them. Also, if you are using pictures, make sure they are of high quality, in case you need to zoom in. Also, a fast computer doesn't hurt.

Take a look at my first attempt:

As you can see, I still had a very hierarchical idea of what my presentation was. Prezi can accomplish this, but it is capable of (and suited to) so much more. I'm looking forward to really exploring it's capabilities.